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KLF4-SQSTM1/p62-associatedprosurvivalautophagycontributestocarfilzomibresistanceinmultiplemyelomamodels
KLF4-SQSTM1/p62相关的生存期自噬与多发性骨髓瘤模型中卡菲佐米耐药有关
Abstract
Multiplemyeloma(MM)isanincurableclonalplasmacellmalignancy.Becauseofahighrateofimmunoglobulinsynthesis,theendoplasmicreticulumofMMcellsissubjectedtoelevatedbasallevelsofstress.Consequently,proteasomeinhibitors,whichexacerbatethisstressbyinhibitingubiquitin-proteasome-mediatedproteindegradation,areanimportantnewclassofchemotherapeuticagentsbeingusedto