北京白癜风手术多少钱 http://m.39.net/pf/a_4785588.html01
KLF4-SQSTM1/p62-associatedprosurvivalautophagycontributestocarfilzomibresistanceinmultiplemyelomamodels
KLF4-SQSTM1/p62相关的生存期自噬与多发性骨髓瘤模型中卡菲佐米耐药有关
Abstract
Multiplemyeloma(MM)isanincurableclonalplasmacellmalignancy.Becauseofahighrateofimmunoglobulinsynthesis,theendoplasmicreticulumofMMcellsissubjectedtoelevatedbasallevelsofstress.Consequently,proteasomeinhibitors,whichexacerbatethisstressbyinhibitingubiquitin-proteasome-mediatedproteindegradation,areanimportantnewclassofchemotherapeuticagentsbeingusedto
